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NFL Odds: Niners vs. Chiefs

Updated: Nov 17, 2021

NFL Odds:

Niners Welcome Chiefs for Preseason Opener

The quarterback battle with the San Francisco 49ers will be in the spotlight this Saturday when they host the Kansas City Chiefs in a rematch of Super Bowl LIV, kicking off at 8:30 PM ET. The Niners are favored by 2.5 points at press time with the total at 36.5.

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It will be interesting to see how San Francisco head coach Kyle Shanahan approaches this game. Jimmy Garoppolo remains their No. 1 QB, but third overall pick Trey Lance is expected to take over at some point. Meanwhile, we’ll might see Patrick Mahomes play the first series for Kansas City.

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